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Proteostasis Consortium

The Proteostasis Consortium is recruiting!

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New Tools for Proteostasis Research

We (the Proteostasis Consortium) are pleased to share the development of new tools for the community.  These tools are designed for your open access here on the Proteostasis Consortium Website.  We invite you to participate in our community effort by sharing your insights. 
 
I. The human proteostasis network has been annotated gene-by-gene by members of the Proteostasis Consortium. This network encompasses genes involved in the synthesis, folding, remodeling, and turnover of proteins, and encompasses nearly 3000 genes and nearly 4000 annotations. Efforts are underway to expand the proteostasis network annotation into model organisms.
 
II. Proteostasis Network Regulators. A listing of curated small molecules that affect different components of the proteostasis network and available information in multiple cell and animal models with pharmacokinetics and pharmacodynamics. These tools are available under the Chemical Probes Annotation page and the Proteostasis Regulator Plates page. 

About Us

The Proteostasis Consortium is a group of investigators who have worked together on proteostasis in biology, health, and diseases. Together, we have contributed fundamental insights on biochemical mechanisms of protein quality control, on cellular and organismal processes, the effects of healthy and unhealthy aging, disease mechanisms, and the development of therapeutic approaches to suppress or delay diseases of protein conformation.

Members of the Proteostasis Consortium include Steve Finkbeiner at the Gladstone Institutes at the University of California San Francisco, Dan Finley at Harvard Medical School, Judith Frydman at Stanford University, Jason Gestwicki at the University of California San Francisco, Jeff Kelly at The Scripps Research Institute, Richard I. Morimoto at Northwestern University, Evan Powers at The Scripps Research Institute, and Miguel Prado at the Instituto de Investigación Sanitari del Principado de Asturia.

We are funded by many sources including the NIH, the Hevolution Foundation, and The Rainwater Charitable Foundation.

Team of Scientists

Steven Finkbeiner, MD, PhD

Steven Finkbeiner, MD, PhD

Director, Center for Systems and
Therapeutics & Taube/Koret Center
for Neurodegenerative Disease,
Gladstone Institutes
Professor, Departments of
Neurology and Physiology,
University of California, San Francisco

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Daniel Finley, PhD

Daniel Finley, PhD

Professor of Cell Biology
Harvard Medical School

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Judith Frydman, PhD

Judith Frydman, PhD

Donald Kennedy Chair in the School of Humanities and Sciences
Professor of Genetics and Biology
Stanford University

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Jason Gestwicki, PhD

Jason Gestwicki, PhD

Associate Director of Academic Affairs
Professor, Department of Pharmaceutical Chemistry
University of California, San Francisco

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Jeffery Kelly, PhD

Jeffery Kelly, PhD

Lita Annenberg Hazen Professor of Chemistry
The Scripps Research Institute

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Richard I. Morimoto, PhD

Richard I. Morimoto, PhD

Bill and Gayle Cook Professor of Biology
Director, Rice Institute for
Biomedical Research
Department of Molecular Biosciences, Northwestern University

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Evan Powers, PhD

Evan Powers, PhD

Institute Investigator
Department of Chemistry
California Campus
Scripps Research

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Miguel Prado, PhD

Miguel Prado, PhD

Institute Investigator
Proteomics and Proteostasis group
Asturias, Spain
Health Research Institute of Asturias (ISPA)

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Announcements

2024 Proteostasis Consortium Seminar Series Schedule

DateSpeakerInstitutionSeminar Title
January 10, 2024Jaroslaw (Jarek) MarszalekUniversity of GdańskHsp70’s client binding cycle - insights from dissecting a highly specialized system
January 17, 2024Alessandro OriGenentech Inc.The Aging Proteome
January 24, 2024Vadim GladyshevHarvard Medical SchoolInsights on aging, longevity and rejuvenation
February 21, 2024Elizabeth RhoadesUniversity of Pennsylvania Modifying α-Synuclein to modulate function
February 28, 2024Ramanujan HegdeMRC Laboratory of Molecular BiologyBiogenesis of the membrane proteome
April 17, 2024Yogesh KulathuUniversity of DundeeRegulation of ER homeostasis by UFM1, the enigmatic ubiquitin-like modifier
April 24-28, 2024Meeting registrationCOLD SPRING HARBORProtein Homeostasis in Health and Disease
May 08, 2024Claudio JoazeiroCenter for Molecular Biology of Heidelberg University (ZMBH)Ribosome-associated Quality Control (RQC): mechanisms, evolution, and role in neurodegeneration
May 22, 2024Barry WillardsonBrigham Young UniversityVisualizing chaperonin-mediated protein folding
June 12, 2024Christian MünchGoethe University Frankfurt – Medical SchoolMitochondrial protein quality control
July 7-11, 2024Meeting registrationFASEBProtein Folding in the Cell
November 06, 2024Ivan DikicGoethe University FrankfurtPathogenic Proteotoxicity of Cryptic Splicing
November 13, 2024Rahul SamantBabraham InstituteDivergent proteostasis strategies underpin senescent cellular states
December 18, 2024Brian FreemanUniversity of Illinois Urbana-ChampaignThe shifting physical interactome of Hsp90 during chronological aging
January 29, 2025Andrew TrumanUniversity of North Carolina at CharlotteUnderstanding the reciprocal interplay between the Hsp70 chaperone code and proteostasis
February 26, 2025Christina WooHarvard UniversityInvestigation of protein damage modifications

PROTEOSTASIS CONSORTIUM WEEKLY SEMINAR SERIES (VIA ZOOM)

VIEW FULL SCHEDULE UNDER SEMINARS

RECORDINGS WILL BE POSTED 3 WEEKS AFTER LIVE SEMINAR DATE UNDER SEMINARS 

Contact:  Rebecca (rebecca.phend@northwestern.edu)

Principal Investigators

Steven Finkbeiner, MD, PhD

Gladstone Institutes at University of California, San Francisco
1650 Owens St., Office 317
San Francisco, CA 94158
415-734-2508
steve.finkbeiner@gladstone.ucsf.edu

Daniel Finley, PhD

Harvard Medical School
240 Longwood Ave
Boston, MA 02115
617-432-3492
daniel_finley@hms.harvard.edu

Judith Frydman, PhD

Stanford University
Clark Center E200
318 Campus Drive
Stanford, CA 94305
650-725-7835
jfrydman@stanford.edu

Jason Gestwicki, PhD

University of California, San Francisco
Gestwicki Laboratory
675 Nelson Rising Lane
San Francisco, CA 94038
(415)502-7121
Jason.Gestwicki@ucsf.edu

Jeff Kelly, PhD

The Scripps Research Institute
10550 North Torrey Pines Road
La Jolla, California 92037
858-784-9880
jkelly@scripps.edu

Richard Morimoto, PhD

Northwestern University
Department of Molecular Biosciences
2220 Campus Drive, Cook Hall, Room 3103
Evanston, IL 60208
847-491-3340
r-morimoto@northwestern.edu 

Evan Powers, PhD

The Scripps Research Institute
10550 North Torrey Pines Road
La Jolla, California 92037
(858) 784-9609
epowers@scripps.edu

Miguel Prado, PhD

Health Research Institute of Asturias (ISPA)
Av. del Hospital Universitario
s/n, 33011 Oviedo
Asturias
Spain
+34 985 10 99 05
miguel.prado@ispasturias.es

 

Contact Us

Northwestern University

Proteostasis Consortium

Grant and Website Administrator
Rebecca Phend (rebecca.phend@northwestern.edu)
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