JAN 6, 2021 – PETER WALTER (HHMI-UCSF)
Targeting the cell’s stress pathways for therapeutic benefit
_____________________________________________________________________________
JAN 13, 2021 – HUDA ZOGHBI (BAYLOR COLLEGE OF MEDICINE)
Genetic and Biochemical Studies to Gain Insight into Neurodegenerative Disorders
_____________________________________________________________________________
JAN 20, 2021 –
RITWICK SAWARKAR (MRC CAMBRIDGE)
Stress-Induced Transcriptional Attenuation (SITA)
SHARON HUNG (HARVARD UNIVERSITY)
Reciprocal regulation between Ubp6 and the proteasome
_____________________________________________________________________________
JAN 27, 2021 – BERND BUKAU (ZMBH/DKFZ)
How newly synthesized proteins reach the native state in the cytosol
_____________________________________________________________________________
FEB 3, 2021 – DAVID AGARD (UCSF)
_____________________________________________________________________________
FEB 10, 2021 – JOHN HARDY (UNIVERSITY COLLEGE OF LONDON)
Genetic analysis of late onset neurodegeneration implicates a failure of damage response
_____________________________________________________________________________
FEB 17, 2021 – JOHANNES BUCHNER (TECHNICAL INSTITUTE MUNICH)
How the Hsp70 and Hsp90 chaperone machineries cooperate
_____________________________________________________________________________
FEB. 24, 2021 – NICOLAS LEHRBACH (FRED HUTCHINSON CANCER RESEARCH CENTER)
Regulation of the proteasome by SKN-1A/Nrf1
_____________________________________________________________________________
MAR 3, 2021 – ALISON GOATE (ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI)
What human genetics tells us about the causes of Alzheimer’s disease
_____________________________________________________________________________
MAR 10, 2021 – ROHIT PAPPU (WASHINGTON UNIVERSITY – ST. LOUIS)
Phase transitions driven by unfolded proteins
_____________________________________________________________________________
MAR 17, 2021 – KEITH BLACKWELL (HARVARD UNIVERSITY)
Coordinating lipid and protein homeostasis to promote longevity
_____________________________________________________________________________
MAR 24, 2021 – ROLAND RIEK (ETH ZURICH)
Structure activity relationship of protein aggregates
_____________________________________________________________________________
MAR 31, 2021 – SUSAN SHAO (HARVARD MEDICAL SCHOOL)
Mechanisms of membrane protein sorting
_____________________________________________________________________________
APR 7, 2021– SUSAN ACKERMAN (UC-SAN DIEGO MEDICAL SCHOOL)
Translation elongation defects and neurodegeneration
_____________________________________________________________________________
APR 14, 2021 – ALWIN KÖHLER (MAX PERUTZ LABS VIENNA-AUSTRIA)
The role of phase separation in nuclear ubiquitin signaling
_____________________________________________________________________________
APR 21, 2021– RACHEL KLEVIT (UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE)
Quasi-order organizes small heat shock proteins for action
_____________________________________________________________________________
APR 28, 2021 – LILA GIERASCH (UNIVERSITY OF MASSACHUSETTS- AMHERST)
How Hsp70s recognize their substrates
_____________________________________________________________________________
MAY 5, 2021 – TODD GOLDE (UNIVERSITY OF FLORIDA)
_____________________________________________________________________________
MAY 12, 2021 – BRENDA SCHULMAN (MAX PLANCK INSTITUTE- MARTINSREID)
Regulation by the ubiquitin system
_____________________________________________________________________________
MAY 19, 2021– DON CLEVELAND (UCSD HEALTH)
Chaperone-regulated phase separation and aggregation of TDP-4
_____________________________________________________________________________
MAY 26, 2021 – THORSTEN HOPPE (UNIVERSITY OF COLOGNE)
Stressed Out: Proteostasis Regulation Mediated by RNA Silencing
_____________________________________________________________________________
JUNE 2, 2021 – ANDREW DILLIN (BERKELEY)
Coordinating the molecular mechanisms of aging for metazoa
_____________________________________________________________________________
JUN 9, 2021 – CYNTHIA KENYON (CALICO LABS)
Regulation of proteostasis in the immortal C. elegans germ lineage
_____________________________________________________________________________
JUN 16, 2021 – DANIEL GOTTSCHLING (CALICO LABS)
Untangling the web of lysosomal homeostasis
_____________________________________________________________________________
JUN 23, 2021 – DAVID HOLTZMAN (WASHINGTON UNIVERSITY SCHOOL OF MEDICINE)
Effect of APOE in models with amyloid or tauopathy
_____________________________________________________________________________
JUN 30, 2021 – NORBERT PERRIMON (HARVARD MEDICAL SCHOOL)
Interorgan communication and the control of homeostasis in Drosophila
_____________________________________________________________________________
JULY 7, 2021 – MANAJIT HAYER-HARTL (MAX PLANCK INSTITUTE – MARTINSRIED)
Multi-protein condensate formation in carboxysome assembly
_____________________________________________________________________________
JULY 14, 2021 – DAVID GLASS (REGENERON PHARMACEUTICALS)
Molecular mechanisms mediating aging-related disorders
_____________________________________________________________________________
JULY 21, 2021 –
PRIYANKA NARAYAN (NIH – NIDDK)
Understanding cellular mechanisms of risk in neurodegenerative disease
JOHN LABBADIA (UNIVERSITY COLLEGE LONDON)
_____________________________________________________________________________
JULY 28, 2021 – AARON GITLER (STANFORD UNIVERSITY)
Expanding mechanisms and therapeutic strategies for ALS
_____________________________________________________________________________
AUG 4, 2021 –
REBECCA TAYLOR (MRC LABORATORY OF MOLECULAR BIOLOGY)
Mechanisms of organismal stress resistance in C. elegans
JESSICA YOUNG (UNIVERSITY OF WASHINGTON)
_____________________________________________________________________________
AUG 11, 2021 – DARCIE MOORE (UNIVERSITY OF WISCONSIN-MADISON)
Aggresomes: a non-universal program for maintaining proteostasis
_____________________________________________________________________________
AUG 18, 2021 – NOBORU MIZUSHIMA (UNIVERSITY OF TOKYO)
Organelle degradation by autophagy-dependent and independent pathways
_____________________________________________________________________________
AUG 25, 2021 – BYRON CAUGHEY (ROCKY MOUNTAIN LABORATORY)
_____________________________________________________________________________
SEPT 1, 2021 –
JEREMY LINSLEY (UCSF – GLADSTONE INSTITUTE)
EMILY SONTAG (MARQUETTE UNIVERSITY)
Sorting out the JUNQ: the Spatial Nature of Protein Quality Control
_____________________________________________________________________________
SEPT 8, 2021 – MATTHIAS MAYER (UNIVERSITY OF HEIDELBERG)
Molecular mechanism of Hsp70 Chaperones: Interactions with cochaperones and substrates
_____________________________________________________________________________
SEPT 15, 2021 – DARYL BOSCO (UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER)
Mechanisms of protein dysfunction in ALS
_____________________________________________________________________________
SEPT 22, 2021 – TOSHI INADA (TOHOKU UNIVERSITY)
Translation quality control and ribosome ubiquitination
_____________________________________________________________________________
SEPT 29, 2021 – ANNE SIMONSEN (UNIVERISTY OF OSLO)
Regulation of selective autophagy by lipid-binding proteins
_____________________________________________________________________________
OCT 6, 2021 – THOMAS LANGER (MAX PLANCK INSTITUTE – COLOGNE)
Reprogramming mitochondria by proteolysis
_____________________________________________________________________________
OCT 13, 2021 – D. ALLAN DRUMMOND (THE UNIVERSITY OF CHICAGO)
Stress-triggered mRNA condensation
_____________________________________________________________________________
OCT 20, 2021 – HELEN SAIBIL (BIRKBECK – UNIVERSITY OF LONDON)
Protein aggregation and disaggregation in vivo and in vitro
_____________________________________________________________________________
OCT 27, 2021 – JEFFREY BRODSKY (UNIVERSITY OF PITTSBURGH)
The many fates of misfolded proteins in the Endoplasmic Reticulum
_____________________________________________________________________________
NOV 3, 2021 – CHRISTINA SIGURDSON (UC SAN DIEGO)
Manipulating prion protein clearance pathways to slow neurodegeneration
_____________________________________________________________________________
NOV 10, 2021 – YIHONG YE (NIH – NIDDK)
Protein misfolding in and out of the cell
_____________________________________________________________________________
NOV 17, 2021 – ONN BRANDMAN (STANFORD UNIVERSITY)
Systems insights of PQC from yeast
_____________________________________________________________________________
DEC 1, 2021 – RANDAL KAUFMAN (SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE)
Clotting factor VIII: From cloning to molecular therapy and beyond to liver disease
_____________________________________________________________________________
DEC 8, 2021 – LEA SISTONEN (UNIVERSITY OF TURKU)
_____________________________________________________________________________
DEC 15, 2021 – JAMES CHEN (UT SOUTHWESTERN)
Ubiquitin Signaling in Innate Immunity
_____________________________________________________________________________
