Proteostasis Consortium

Associate or Full Specialist

Senior Scientist, Drug Discovery for Age-Associated Disease

The Gestwicki Laboratory and the Small Molecule Discovery Center (SMDC)
Department of Pharmaceutical Chemistry
University of California, San Francisco

The Gestwicki laboratory at UCSF is seeking a highly collaborative drug discovery professional to help lead an exciting project at the interface of aging, longevity and chemical biology. Funded by a 5+ year award, the goals of the project are to profile age-related changes in protein homeostasis (proteostasis) and explore small molecule-based strategies for restoring healthy aging. The successful individual will independently develop the project to achieve key milestones, while working with an exciting, interdisciplinary team of scientists that are located at top academic centers.

The SMDC is a research “Collaboratory” that works with academic and industry researchers to develop chemical probes and drug leads. The successful applicant will work with this team to design and execute biophysical and biochemical assays. Scientists who enjoy working on diverse problems and thrive in a team-oriented, multi-disciplinary environment are ideally suited for this position.
The position will report to Dr. Jason Gestwicki, Professor of Pharmaceutical Chemistry. The Department of Pharmaceutical Chemistry is one of the three departments in the School of Pharmacy, one of the top ranked schools of Pharmacy in the US.
To learn about our science, visit our websites at:
https://pharm.ucsf.edu/smdc
https://gestwickilab.ucsf.edu

Responsibilities include:

• Lead an internal research team to achieve key milestones in drug discovery for age-associated disorders
• Development and application of screening assays
• Management and expansion of a small molecule compound collection
• Interface with external collaborators
• Mentorship of junior trainees
• Preparation of reports
• Independent exploration of new targets

Required Qualifications

• Ph.D. in chemistry, pharmacology or life sciences
• 5+ years of research experience, including at least 3 years in the biotechnology/pharmaceutical industry
• Experience working in a team research environment
• Strong written and communication skills

Preferred Qualifications

• Experience with automated microscopy and phenotypic assays
• Experience in multi-site project management
• Experience with small molecule handling, storage and quality assurance.
• Background in pharmacology and/or medicinal chemistry

Salary will be commensurate with the applicant’s experience and training.

Applicants should submit a brief cover letter and a curriculum vitae. Please apply online and submit these documents along with the contact information for at least two references to: https://aprecruit.ucsf.edu/apply/XXX.

UCSF seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment of diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.