[rph835]

Research Fellow in Structural Biology
To investigate how proteins aggregate into amyloid fibrils, and how fibrils with different structure perturb cellular function. This BIRAX-funded role is to use cryoEM, supported with other biochemical and biophysical analyses, to understand the structure of amyloid fibrils formed in vitro and purified from patient samples and to determine the activity of different fibril types in causing neuronal dysfunction. This will help to reveal the mechanisms by which disease-relevant mutations and post-translational modifications effect changes in amyloid aggregate formation, and the consequences of aggregation on cellular function. You should have (or be close to completing) a PhD in Structural Biology, Biochemistry, or a related discipline, and extensive experience of using structural methods to elucidate biological mechanisms. Experience in cryo-electron microscopy would be a significant advantage, but training would be given to an outstanding structural biologist lacking this experience but able to prove their passion and commitment to learn cryo-EM techniques.

Please see https://jobs.leeds.ac.uk/Vacancy.aspx?ref=FBSAC1008

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