Proteostasis Consortium

The Proteostasis Pharmacology Subgroup of the Proteostasis Consortium was formed to coordinate the discovery, characterization and use of small molecule modulators of the Proteostasis Network. Our goals are to (i) develop new chemical probes for high value targets in the Proteostasis Network, (ii) share current information about the best validated chemical probes with members of the Proteostasis Consortium and beyond (iii) build and maintain a collection of best-in-class chemical probes for a range of targets in the Proteostasis Network. The long term goal of our subgroup is to identify ways of using small molecules to delay or reverse age-dependent neurodegenerative diseases.

Towards these goals, the Proteostasis Pharmacology Subgroup is currently developing two resources (see New Tools tab). The first resource is an annotated list of small molecules that have undergone rigorous evaluation as chemical probes. The second is to an up-to-date list of publicly available small molecules that perturb targets in the Protoestasis Network. This validated collection, once established and fully characterized, will be made available to the proteostasis research community at-large.

Finally, research programs being conducted within the Proteostasis Consortium and our collaborators are building new tools for targeting the major degradation pathways (e.g., autophagy and the proteasome). As these tools advance, they will also be shared with the wider research community.